Fluoxetine metabolism

The metabolism of Vonoprazan can be increased when combined with Fluocortolone. Fluoxetine, The metabolism of Fluoxetine can be decreased when combined with

Fluoxetine is extensively metabolized in the liver. The only identified active metabolite, norfluoxetine, is formed by demethylation of fluoxetine.

In a study involving labeled and unlabeled enantiomers administered as a racemate, these individuals metabolized S-fluoxetine at a slower rate and thus achieved higher concentrations of S-fluoxetine. Consequently, concentrations of S-norfluoxetine at steady state were lower. The metabolism of R-fluoxetine in these poor metabolizers appears normal.

Fluoxetine. Sildenafil, The serum concentration of Sildenafil can be increased when it is combined with Fluoxetine. Siltuximab, The metabolism of Fluoxetine

fluoxetine. fluoxetine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. fluoxetine

Fluoxetine-bupropion Bupropion inhibits CYP2D6 which metabolizes fluoxetine. Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination

Valium Fluoxetine. Fluoxetine is an inhibitor of an enzyme that metabolizes Valium. Thus, when this combination is used together, the

Figure 1 Fluoxetine metabolism. Fluoxetine is metabolized primarily by CYP2D6; however, fluoxetine and its metabolites (r-norfluoxetine

Fluoxetine is a moderate inhibitor of drugs metabolized by CYP2D6 but a strong inhibitor of drugs metabolized by CYP2C19. Since CBD and fluoxetine compete for metabolism in the liver, serum levels of both compounds can elevate. This slows fluoxetine s metabolization, which, in turn, increases the possibility of side effects.