A study comparing the effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock receiving norepinephrine. The study used a target trial approach and adjusted for baseline covariates and propensity scores.
Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis.
Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med. 2024 Mar 1;378(9): . Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock. JAMA Intern Med. 2024 May 1;183(5): .
They found that the regimen of hydrocortisone and fludrocortisone together was superior to hydrocortisone alone; on average, patients who
Given the potential for a clinically significant benefit of hydrocortisone-fludrocortisone combination therapy compared with hydrocortisone alone, this study used target trial emulation to evaluate the effectiveness of the addition of fludrocortisone to hydrocortisone vs hydrocortisone alone in patients with septic shock admitted to U.S. hospitals.
Drugs Comparison (Drug Vs. Drug) Vitamins Supplements Drug The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone.
Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone in Septic Shock. Podcast Episode; 2024; 16m. YOUR RATING.
Mortality was significantly lower in the hydrocortisone-plus-fludrocortisone group than in the placebo group at ICU discharge (35.4% vs. 41.0%, P=0.04), hospital discharge (39.0% vs. 45.3%
Rationale: The use of hydrocortisone in adult patients with septic shock is controversial, and the effectiveness of adding fludrocortisone to hydrocortisone remains uncertain. Objectives: To assess the comparative effectiveness and safety of fludrocortisone plus hydrocortisone, hydroco
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