The bioavailability of morphine is %. There is significant first-pass metabolism, therefore oral doses are 6 times larger than parenteral doses to achieve the same effect. Morphine reaches steady-state concentrations after hours. Parenteral morphine has a T max of 15 minutes and oral morphine has a T max of 90 minutes, with a C max
Beware of small doses as these are equivalent to a much larger dose of morphine: 1mg = 30mg oral morphine. morphine IR 1-5mg PRN max hourly. Once a
Max dose is 300 mg bid. Reduce dose in renal Total daily oral morphine dose. Estimated oral methadone as a % of total daily morphine.
The bioavailability of morphine is %. There is significant first-pass metabolism, therefore oral doses are 6 times larger than parenteral doses to achieve the same effect. Morphine reaches steady-state concentrations after hours. Parenteral morphine has a T max of 15 minutes and oral morphine has a T max of 90 minutes, with a C max
To calculate the dose of SC morphine, divide total dose of oral morphine by 2. (Max dose = 25mg/24 hours). Is the metoclopramide effective? Yes. No. Yes.
Morphine (Oramorph) PRN, max hourly. You wish to prescribe One sixth of this is the 4hrly dose – prescribe 5mg Morphine subcutaneously PRN, max hourly.
There is significant first-pass metabolism, therefore oral doses are 6 times larger than parenteral doses to achieve the same effect. Morphine reaches steady-state concentrations after hours. Parenteral morphine has a T max of 15 minutes and oral morphine has a T max of 90 minutes, with a C max of 283nmol/L. The AUC of morphine is 225
The bioavailability of morphine is %. There is significant first-pass metabolism, therefore oral doses are 6 times larger than parenteral doses to achieve the same effect. Morphine reaches steady-state concentrations after hours. Parenteral morphine has a T max of 15 minutes and oral morphine has a T max of 90 minutes, with a C max
Then convert the morphine equivalent dose to the new drug utilizing the table. MAX BOLUS DOSE. MAX INFUSION RATE. Ropivacaine. 2mon: 4mg/kg. 2mon: 0.3mg
Regards, Jack