Olaparib liver injury

☑️@olaparib_liver_injur · 7955 subscribers · Content 18+ 🔞
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Actual: The first case in the United States of an acute and severe liver injury with associated jaundice and liver synthetic dysfunction secondary to olaparib is reported. ABSTRACT Immune-mediated drug-induced liver injury can be triggered by multiple classes of medications including immunotherapies.
4.9 rating 2025-04-24
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disease' versus 'exposure in patients with hepatic impairment There were no changes to suggest that olaparib causes liver injury, and there

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Olaparib therapy is associated with a low rate of transient elevations in serum aminotransferase during therapy and has not been linked to instances of clinically apparent liver injury. Sections OVERVIEW

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The PARP inhibitor olaparib (Lynparza) is a recently FDA-approved therapy for cancer. This study shows that PARP is overactivated in livers of subjects with alcoholic liver disease and that pharmacological inhibition of this enzyme with 3 different PARP inhibitors, including olaparib, attenuates high fat or alcohol induced liver injury, abnormal

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Also, olaparib was not protecting the changes in MPO in liver and kidney. No effect of olaparib was noted on MDA concentrations in lung 7 d after injury. Olaparib also attenuated the increases in plasma markers of pancreatic and renal injury. It affected one liver injury marker (ALT) but not ALP. Limitations: [B], [C], [E], [I], and [J]. 84

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Durvalumab, Placebo for Olaparib, Olaparib, Nab-paclitaxelcarboplatin Drug-induced liver injury1. participants affected / at risk, 2/401 (0.50%), 0

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Challenges in PARP inhibitor therapy: A case of Olaparib-induced liver injury and successful rechallenge with Niraparib.

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Olaparib; Oliceridine; Omaveloxolone; Omeprazole; Osimertinib; Ospemifene Liver diseaseUse with caution. May make these conditions worse. Kidney

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Conversely, Rucaparib is extensively metabolized by cytochrome P450 enzymes and may be at high risk of cross reactivity in the setting of Olaparib-induced liver injury. Rechallenge with another PARPi after Olaparib-induced liver injury should carefully balance the potential clinical benefits against the risk of triggering severe hepatotoxicity.

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Olaparib-Induced Immune-Mediated Liver Injury. Alshelleh M, Park J, John V, Rishi A, Bernstein D, Roth N ACG Case Rep J, 9(1):e

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