The uricosuric agents act on the proximal tubule of the kidney inhibiting uric acid reabsorption and/or increasing uric acid secretion. Uricosuric drugs are
The use of loop and thiazide diuretics can increase uric acid levels, whereas the use of the angiotensin receptor blocker losartan increases urinary excretion of uric acid. Reduction of uric acid
Pyrazinamide and Ethambutol are antitubercular drugs that raise Uric acid levels by lowering excretion and increasing uric acid reabsorption and cause life-
Diuretics are one of the most important causes of secondary hyperuricaemia. Drugs raise serum uric acid level by an increase of uric acid reabsorption and/or decrease in uric acid secretion. Several drugs may also increase uric acid production.
Antihypertensive drugs either increase serum uric acid levels (e.g, diuretics, β-blockers) or decrease serum uric acid levels (e.g.
Foods high in purines increase uric acid levels. Drugs such as aspirin, penicillin, diuretics and insulin may Alcohol increases uric acid production and
drugs that increase urine excretion of uric acid (probenecid). Another drug, pegloticase, actively breaks down uric acid, and can be used
Newer uricosuric drugs improve treatment by increasing the excretion of uric acid and reduce the concentration of uric acid in blood plasma. In
Drugs: The use of immuno-suppressant drugs may lead to high uric acid in the body. uric acid levels in the body from increasing further.
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