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Can you take ibuprofen (Advil) with cyclobenzaprine? expand_more. Cyclobenzaprine isn't known to interact with ibuprofen (Advil, Motrin). Cyclobenzaprine can
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Interactions between Cyclobenzaprine and Ibuprofen How Cyclobenzaprine Interacts with Ibuprofen. When taken together, Cyclobenzaprine and Ibuprofen may interact in the body. Both medications have sedative effects, which means that combining them may increase the likelihood of experiencing drowsiness, dizziness, and impaired coordination.
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