Settling the Methadone IV Debate / Methadone 5mg IV Report I've looked around various forums for opinions on injecting methadone tablets
Meperidine. PO. 1 mg ; Methadone. IV. 1mg ; Methadone. PO. 1mg ; Morphine. IV. 1 mg ; Morphine. Epidural. 1 mg.
Methadone is not renally cleared; its use is acceptable in renal failure. The potency of iv methadone is approximately equivalent to iv morphine. The (d) isomer of methadone acts like ketamine - a NMDA antagonist.
Calculation of Oral Morphine Equivalents (OME) ; Meperidine. PO. 1 mg ; Methadone. IV. 1mg ; Methadone. PO. 1mg ; Morphine. IV. 1 mg ; Morphine. Epidural. 1 mg.
Alternatives to conversion to IV methadone include conversion to a different oral or IV opioid (at an equivalent dose) or consider converting oral methadone to
Meperidine. PO. 1 mg ; Methadone. IV. 1mg ; Methadone. PO. 1mg ; Morphine. IV. 1 mg ; Morphine. Epidural. 1 mg.
Example of 1:1.3 ratio (IV to oral): 8 mg of IV methadone equals ~10 mg of oral methadone. (NZ) New Zealand: Methadone
methadone or 3-5% IV methadone as percent of morphine equivalent dose; 1,000 mg morphine equivalent dose: Administer 5 % oral methadone or 3% IV
Popular tertiary references suggest a conversion ratio of oral to IV methadone of 2:1, meaning 10 mg of oral methadone is equivalent to 5 mg of IV methadone.
Comments
The main character falls unconscious in a hospital. “IV”. Think about it.