Chloride channel activator

Lubiprostone: A Chloride Channel Activator for Treatment of Chronic Constipation 40 Citations 20 References.

Recent advances have been made in the molecular identification of these channels and in the identification of channel activators and inhibitors. Chloride channels activated by GABA (

Activation of ClC-2 chloride channels causes an efflux of chloride ions into the lumen, which in turn leads to an efflux of sodium ions through a paracellular

DRUG CLASS: Gastrointestinal Chloride Channel Activators Amitiza is a type-2 chloride channel activator that stimulates chloride secretion in

Relistor (methylnaltrexone), and Movantik. (naloxegol). Amitiza is a chloride channel activator. Relistor and Movantik are opioid antagonists.

Chloride channel activators can be used to treat IBS-related constipation. The activation of chloride channels in the intestine stimulates the

Calcium-activated Chloride Channel Activators ; 4876, Eact ; Activator of Ca2-activated Cl- channel transmembrane protein 16A (TMEM16A)

Upon activation by light, these channels and pumps respond by opening or Chloride-conducting channel, Step-waveform inhibitory ChR with mutation

Chloride channel activators . Chloride channels located on intestinal epithelial cells regulate intestinal motility and fluid secretion. 92 Activation of type‐2 chloride channels triggers the release of chloride ions into the intestinal lumen. 92 The resulting ion gradient promotes sodium and water release into the lumen, increasing stool