Drugs that increase uric acid excretion

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Actual: Probenecid (Probalan), a uricosuric agent that increases renal uric acid excretion, is associated with an increased risk of drug interactions
4.4 rating 2025-04-24
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Lesinurad is an investigational agent that inhibits the URAT1 transporter, increasing uric acid excretion and thereby lowering serum uric acid (

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Newer uricosuric drugs improve treatment by increasing the excretion of uric acid and reduce the concentration of uric acid in blood plasma. In

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Allopurinol reduces both the serum and urinary uric acid levels by inhibiting the formation of uric acid. The use of allopurinol to block the formation of urates avoids the hazard of increased renal excretion of uric acid posed by uricosuric drugs.

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Uricosuric agents (e.g, probenecid) increase the excretion of uric acid, which can accelerate the formation of stones. Uric acid stones are

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Uricosuric medications are the substances that increase the excretion of uric acid in urine, thus reducing the concentration of uric acid in blood plasma.

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Elevated uric acid is due to either increased production or decreased excretion by the kidney. The excess uric acid is deposited as needle-like

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Amlodipine and Losartan as known to be uricosic (increase excretion of uric acid.) First experience with gout despite normal uric acid levels.

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Newer uricosuric drugs improve treatment by increasing the excretion of uric acid and reduce the concentration of uric acid in blood plasma. In

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Currently, urate excretion-promoting drugs used in the clinic primarily act on URAT1 and increase uric acid excretion by inhibiting uric acid reabsorption in the proximal renal tubules.

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