Effect on OCD symptoms can take up to 12 weeks, may require upper end of Evidence to support the use of clonidine and guanfacine for reduction.
Patients with OCD tics show less robust response to SSRIs Clonidine (alpha-agonist). Methylphenidate (stimulant). Combined
First-tier: Alpha-agonists (clonidine, guanfacine). Second-tier: Atypical to those with OCD without tics (Pediatric OCD Treatment Study – 2024).
by S Akouchakian 2024 Cited by 2In the recent experimental study, clomipramine and clonazepam, but not clonidine, significantly improved OCD symptoms. However, clonidine was remarkably
The alpha-nists clonidine Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence.
Side effects of clonidine include dose-related and time-limited symptoms such as dizziness, drowsiness, depression, orthostasis, bradycardia, dry mouth, and constipation - with rebound hypertension being the primary risk of sudden discontinuation . Clonidine is currently not FDA-approved for the treatment of OCD.
by E Hollander 2024 Cited by 102Blood pressure and pulse in response to clonidine did not differ between groups. Improvement in OCD symptoms after clonidine significantly correlated with GH
clonidine to treat hyperactivity associated with ADHD: attention-deficit/hyperactivity disorder; OCD: obsessive-compulsive disorder; TD: tic disorder
by WA Hewlett 2024 Cited by 207Compared 3 medications (clomipramine, clonazepam, and clonidine) with reported efficacy in obsessive-compulsive disorder (OCD) to a control medication
All the best.