renal function, the advice given in Dosage in renal impairment A reduction in the dose of allopurinol is therefore required in patients with
Use: For the chronic management of hyperuricemia in patients with gout who have an inadequate experience to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable. Renal Dose Adjustments. Mild to Moderate Renal Dysfunction: No adjustment recommended
Renal impairment: Start Lowering the starting dose of allopurinol appropriate to the level of renal function reduces the risk of allopurinol.
Alternatively, colchicine Lowering the starting dose of allopurinol appropriate to the level of renal function reduces the risk of allopurinol.
Renal-dosing of allopurinol compounds the poor management of gout and adds to the perception that allopurinol may be detrimental for renal
4 Allopurinol dose needs to be adjusted in renal failure. Maximum daily dose of allopurinol is 800 mg/day. Dose adjustments may be necessary if allopurinol
Allopurinol. Allopurinol has a renally excreted active metabolite that accumulates in renal impairment and may cause adverse effects if the dose is not adjusted
Allopurinol. Allopurinol has a renally excreted active metabolite that accumulates in renal impairment and may cause adverse effects if the dose is not adjusted
doses in patients with renal insufficiency because of the risk of allopurinol hypersensitivity. Gradual allopurinol dose escalation, in
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